Tsis muaj kev kho rau tus kab mob Alzheimer's, tab sis cov kws tshawb fawb yeej ib txwm tshawb nrhiav txoj hauv kev los kho cov tsos mob ntawm tus kab mob.
Cov kws tshawb nrhiav kuj tseem tab tom ua haujlwm rau kev kuaj pom thaum ntxov ntawm kev puas hlwb uas cuam tshuam nrog tus kab mob Alzheimer, vim tias kev kuaj pom thaum ntxov tuaj yeem pab kho tau.
Ib txoj kev tshawb fawb tshiab luam tawm hauv Frontiers in Aging Neuroscience qhia tias uroformic acid tuaj yeem yog ib qho biomarker rau kev kuaj mob Alzheimer's thaum ntxov.
Lub Chaw Tswj thiab Tiv Thaiv Kab Mob hauv Tebchaws Meskas (CDC) piav txog tus kab mob dementia tias yog "kev puas tsuaj hauv kev nco, kev xav, lossis kev txiav txim siab uas cuam tshuam rau cov dej num niaj hnub."
Ntxiv rau tus kab mob Alzheimer's, muaj lwm hom kev puas hlwb xws li kev puas hlwb nrog Lewy lub cev thiab kev puas hlwb vascular. Tab sis Alzheimer's yog hom kev puas hlwb uas pom ntau tshaj plaws.
Raws li daim ntawv qhia xyoo 2022 ntawm Alzheimer's Disease Association, muaj li ntawm 6.5 lab tus tib neeg hauv Tebchaws Meskas uas muaj tus kab mob no. Tsis tas li ntawd xwb, cov kws tshawb fawb xav tias tus lej ntawd yuav nce ob npaug los ntawm xyoo 2050.
Tsis tas li ntawd xwb, cov neeg uas muaj tus kab mob Alzheimer's theem siab yuav muaj teeb meem nqos, hais lus, thiab taug kev.
Txog rau thaum ntxov xyoo 2000s, kev kuaj lub cev yog tib txoj kev los paub tseeb tias ib tus neeg puas muaj tus kab mob Alzheimer lossis lwm hom kev puas hlwb.
Raws li Lub Koom Haum National Institute on Aging, cov kws kho mob tam sim no tuaj yeem ua qhov lumbar puncture, tseem hu ua lumbar puncture, los xyuas cov biomarkers cuam tshuam nrog Alzheimer's tus kab mob.
Cov kws kho mob nrhiav cov cim qhia txog cov kab mob xws li beta-amyloid 42 (ib qho tseem ceeb ntawm cov amyloid plaques hauv lub hlwb) thiab tej zaum yuav nrhiav cov teeb meem tsis zoo ntawm daim duab PET scan.
"Cov txheej txheem tshiab los thaij duab, tshwj xeeb tshaj yog kev thaij duab amyloid, PET amyloid imaging, thiab tau PET imaging, tso cai rau peb pom cov teeb meem tsis zoo hauv lub hlwb thaum ib tus neeg tseem muaj sia nyob," tus xibfwb thiab kws kho mob hauv Michigan Public Health Kenneth M., Dr. Langa hais. Hauv Ann Arbor, uas tsis koom nrog txoj kev tshawb fawb no, tau hais lus rau hauv Michigan Medicine podcast tsis ntev los no.
Muaj ntau txoj kev kho mob uas yuav pab txo qhov hnyav ntawm cov tsos mob ntawm tus mob hawb pob thiab ua kom qeeb qeeb ntawm tus kab mob, txawm hais tias lawv kho tsis tau nws.
Piv txwv li, tus kws kho mob yuav sau ntawv kom noj tshuaj xws li donepezil lossis galantamine los txo cov tsos mob ntawm tus mob hawb pob. Ib yam tshuaj uas tab tom tshawb nrhiav hu ua lecanemab kuj tseem yuav ua rau qeeb qeeb ntawm tus kab mob Alzheimer's.
Vim tias kev kuaj mob Alzheimer's tus kab mob kim heev thiab tej zaum yuav tsis muaj rau txhua tus, qee cov kws tshawb fawb tab tom muab qhov tseem ceeb rau kev kuaj mob thaum ntxov.
Cov kws tshawb fawb los ntawm Shanghai Jiao Tong University thiab Wuxi Institute of Diagnostic Innovation hauv Suav teb tau ua ke tshuaj xyuas lub luag haujlwm ntawm formic acid ua ib qho biomarker rau tus kab mob Alzheimer hauv cov zis.
Cov kws tshawb fawb tau xaiv cov tshuaj no raws li lawv txoj kev tshawb fawb yav dhau los txog cov cim qhia txog tus kab mob Alzheimer. Lawv taw qhia rau qhov tsis zoo ntawm formaldehyde metabolism ua ib qho tseem ceeb ntawm kev puas tsuaj ntawm kev paub txog hnub nyoog.
Rau txoj kev tshawb fawb no, cov kws sau ntawv tau nrhiav 574 tus neeg koom nrog los ntawm Memory Clinic ntawm Sixth People's Hospital ntawm Shanghai, Suav teb.
Lawv tau faib cov neeg koom nrog ua tsib pawg raws li lawv qhov kev ua tau zoo ntawm kev xeem ntawm kev ua haujlwm ntawm lub hlwb; cov pab pawg no suav nrog kev paub txog kev noj qab haus huv mus rau Alzheimer's:
Cov kws tshawb nrhiav tau sau cov qauv zis los ntawm cov neeg koom nrog rau cov theem formic acid thiab cov qauv ntshav rau kev tshuaj xyuas DNA.
Los ntawm kev sib piv cov theem ntawm formic acid hauv txhua pawg, cov kws tshawb fawb tau kawm tias muaj qhov sib txawv ntawm cov neeg koom nrog kev noj qab haus huv thiab cov neeg uas tsawg kawg yog ib feem tsis zoo.
Pawg neeg uas muaj qee qib kev poob qis ntawm kev xav muaj cov kua qaub formic ntau dua hauv cov zis dua li pawg neeg noj qab haus huv zoo.
Ntxiv rau, cov neeg koom nrog uas muaj tus kab mob Alzheimer muaj cov kua qaub formic ntau dua hauv lawv cov zis dua li cov neeg koom nrog kev noj qab haus huv.
Cov kws tshawb fawb kuj pom tias cov theem ntawm cov kua qaub hauv cov zis muaj feem cuam tshuam nrog kev ntsuam xyuas kev paub hauv kev nco thiab kev mloog zoo.
Cov kws sau ntawv sau tias "Cov theem ntawm cov kua qaub hauv cov zis tau nce siab heev hauv pawg neeg kuaj mob [uas muaj kev poob qis ntawm kev paub], uas txhais tau tias cov kua qaub hauv cov zis tuaj yeem siv rau kev kuaj mob thaum ntxov [ntawm tus kab mob Alzheimer]."
Cov txiaj ntsig ntawm txoj kev tshawb fawb no tseem ceeb rau ntau yam, tsis yog qhov tsawg kawg nkaus ntawm tus nqi siab ntawm kev kuaj mob Alzheimer's tus kab mob.
Yog tias kev tshawb fawb ntxiv qhia tau tias uric acid tuaj yeem ntes tau kev poob qis ntawm kev paub, qhov no tuaj yeem ua pov thawj tias yog ib qho kev sim yooj yim siv thiab pheej yig.
Ntxiv mus, yog tias qhov kev kuaj mob zoo li no tuaj yeem pom kev poob qis ntawm kev xav uas cuam tshuam nrog tus kab mob Alzheimer, cov kws kho mob tuaj yeem cuam tshuam sai dua.
Dr. Sandra Petersen, DNP, tus lwm thawj coj ntawm kev noj qab haus huv thiab kev nyob zoo ntawm Pegasus Senior Living, tau hais txog txoj kev tshawb fawb no hauv kev xam phaj nrog Medical News Today:
"Kev hloov pauv ntawm tus kab mob Alzheimer pib li ntawm 20 txog 30 xyoo ua ntej kuaj pom thiab feem ntau tsis pom kom txog thaum muaj kev puas tsuaj loj heev. Peb paub tias kev kuaj pom thaum ntxov tuaj yeem muab rau cov neeg mob ntau txoj kev xaiv kho mob thiab muaj peev xwm npaj rau kev saib xyuas yav tom ntej."
"Kev tshawb pom tshiab hauv qhov kev kuaj mob no (tsis yog phais thiab pheej yig) uas muaj rau pej xeem yuav yog qhov hloov pauv loj hauv kev sib ntaus sib tua kab mob Alzheimer," Dr. Peterson hais.
Cov kws tshawb fawb nyuam qhuav tshawb pom ib qho biomarker uas tuaj yeem pab cov kws kho mob kuaj mob Alzheimer's thaum ntxov. Qhov no yuav tso cai rau cov kws kho mob ...
Cov txiaj ntsig ntawm kev tshawb fawb tshiab hauv nas yuav muaj ib hnub pab tsim kev kuaj ntshav uas yuav dhau los ua ib feem ntawm kev tshuaj xyuas niaj hnub rau Alzheimer's thiab lwm yam kev mob nkeeg ...
Ib txoj kev tshawb fawb tshiab siv PET lub hlwb scans los kwv yees qhov kev poob qis ntawm kev paub raws li qhov muaj cov amyloid thiab tau proteins hauv lub hlwb, txwv tsis pub kev paub ...
Cov kws kho mob tam sim no siv ntau yam kev kuaj mob thiab kev ntsuas los kuaj mob Alzheimer's. Cov kws tshawb fawb tau tsim ib qho algorithm uas siv tau rau ib qho ...
Kev kuaj qhov muag sai sai yuav muab cov ntaub ntawv tseem ceeb txog kev noj qab haus huv ntawm lub hlwb rau ib hnub. Qhov tshwj xeeb, nws tuaj yeem kuaj pom cov cim qhia ntawm kev puas hlwb.