Tsis muaj kev kho rau tus kab mob Alzheimer's, tab sis cov kws tshawb fawb yeej ib txwm tshawb nrhiav txoj hauv kev los kho cov tsos mob ntawm tus kab mob.
Cov kws tshawb nrhiav kuj tseem tab tom ua haujlwm rau kev kuaj pom thaum ntxov ntawm kev puas hlwb uas cuam tshuam nrog tus kab mob Alzheimer, vim tias kev kuaj pom thaum ntxov tuaj yeem pab kho tau.
Raws li kev tshawb fawb tshiab luam tawm hauv Frontiers in Aging Neuroscience, cov kua qaub hauv cov zis tuaj yeem yog cov cim qhia txog kev kuaj mob Alzheimer's thaum ntxov.
Lub Chaw Tswj thiab Tiv Thaiv Kab Mob hauv Tebchaws Meskas (CDC) piav txog kev mob dementia tias yog "kev puas tsuaj hauv kev nco, kev xav, lossis kev txiav txim siab uas cuam tshuam rau kev ua ub ua no txhua hnub."
Ntxiv rau tus kab mob Alzheimer's, muaj lwm hom kev puas hlwb xws li kev puas hlwb nrog Lewy lub cev thiab kev puas hlwb vascular. Tab sis Alzheimer's yog hom kev puas hlwb uas pom ntau tshaj plaws.
Raws li daim ntawv qhia xyoo 2022 ntawm Alzheimer's Disease Association, muaj li ntawm 6.5 lab tus tib neeg hauv Tebchaws Meskas uas muaj tus kab mob no. Tsis tas li ntawd xwb, cov kws tshawb fawb xav tias tus lej ntawd yuav nce ob npaug los ntawm xyoo 2050.
Tsis tas li ntawd xwb, cov neeg uas muaj tus kab mob Alzheimer's theem siab yuav muaj teeb meem nqos, hais lus, thiab taug kev.
Txog rau thaum ntxov xyoo 2000s, kev kuaj lub cev yog tib txoj kev los paub tseeb tias ib tus neeg muaj tus kab mob Alzheimer lossis lwm hom kev puas hlwb.
Raws li Lub Koom Haum National Institute on Aging, cov kws kho mob tam sim no tuaj yeem ua qhov lumbar puncture, tseem hu ua lumbar puncture, los xyuas cov biomarkers cuam tshuam nrog Alzheimer's tus kab mob.
Cov kws kho mob nrhiav cov cim qhia txog cov kab mob xws li beta-amyloid 42, uas yog cov khoom tseem ceeb ntawm cov amyloid plaques hauv lub hlwb, thiab tej zaum yuav nrhiav cov teeb meem tsis zoo ntawm daim duab PET scan.
"Cov txheej txheem tshiab los thaij duab, tshwj xeeb yog kev thaij duab amyloid, kev thaij duab amyloid PET, thiab kev thaij duab tau PET, tso cai rau peb pom qhov tsis zoo hauv lub hlwb thaum ib tus neeg tseem muaj sia nyob," tus xibfwb qhia kev noj qab haus huv thiab tus kws kho mob Kenneth M. Dr. Langa. hauv Ann Arbor, uas tsis koom nrog txoj kev tshawb fawb no, tau hais rau hauv Michigan Medicine podcast tsis ntev los no.
Qee txoj kev kho mob tuaj yeem pab txo qhov hnyav ntawm cov tsos mob ntawm tus mob hawb pob thiab qeeb qeeb qhov kev loj hlob ntawm tus kab mob, txawm hais tias lawv tsis tuaj yeem kho nws.
Piv txwv li, tus kws kho mob yuav sau ntawv kom noj tshuaj xws li donepezil lossis galantamine los txo cov tsos mob ntawm tus mob hawb pob. Ib yam tshuaj uas tab tom tshawb nrhiav hu ua lecanemab kuj tseem yuav ua rau qeeb qeeb ntawm tus kab mob Alzheimer's.
Vim tias kev kuaj mob Alzheimer's tus kab mob kim heev thiab tej zaum yuav tsis muaj rau txhua tus, qee cov kws tshawb fawb tab tom muab qhov tseem ceeb rau kev kuaj mob thaum ntxov.
Cov kws tshawb fawb los ntawm Shanghai Jiaotong University thiab WuXi Institute of Diagnostic Innovation ntawm Tuam Tshoj tau ua ke tshuaj xyuas lub luag haujlwm ntawm formic acid ua ib qho biomarker ntawm tus kab mob Alzheimer hauv cov zis.
Cov kws tshawb fawb tau xaiv cov tshuaj no raws li kev tshawb fawb txog tus kab mob Alzheimer yav dhau los. Lawv sau tseg tias kev hloov pauv formaldehyde tsis zoo yog ib qho tseem ceeb ntawm kev puas tsuaj ntawm kev paub txog hnub nyoog.
Rau txoj kev tshawb fawb no, cov kws sau ntawv tau nrhiav 574 tus neeg koom nrog los ntawm Memory Clinic ntawm Sixth People's Hospital ntawm Shanghai, Suav teb.
Lawv tau faib cov neeg koom nrog ua tsib pawg raws li lawv ua tau li cas ntawm kev xeem ntawm kev ua haujlwm ntawm lub hlwb; cov pab pawg no suav nrog kev paub txog kev noj qab haus huv mus rau tus kab mob Alzheimer:
Cov kws tshawb nrhiav tau sau cov qauv zis los ntawm cov neeg koom nrog rau cov theem formic acid thiab cov qauv ntshav rau kev tshuaj xyuas DNA.
Los ntawm kev sib piv cov theem ntawm formic acid hauv txhua pawg, cov kws tshawb nrhiav pom qhov sib txawv ntawm cov neeg koom nrog kev noj qab haus huv thiab cov neeg uas muaj tsawg kawg yog qee qib kev puas siab puas ntsws.
Hauv cov pab pawg uas muaj qee qib kev poob qis ntawm kev xav, qib ntawm formic acid hauv cov zis siab dua li cov pab pawg uas muaj kev ua haujlwm ntawm kev xav zoo.
Ntxiv rau, cov neeg koom nrog uas muaj tus kab mob Alzheimer muaj cov kua qaub formic ntau dua hauv lawv cov zis dua li cov neeg koom nrog kev noj qab haus huv.
Cov kws tshawb fawb kuj pom muaj kev sib raug zoo tsis zoo ntawm qib ntawm formic acid hauv cov zis thiab kev ntsuam xyuas kev paub hauv thaj chaw ntawm kev nco thiab kev mloog zoo.
Cov kws sau ntawv sau tias, "UA tau nce siab heev hauv pawg neeg kuaj mob [uas muaj kev poob qis ntawm kev paub], uas txhais tau tias UA tuaj yeem siv rau kev kuaj mob thaum ntxov [ntawm tus kab mob Alzheimer]."
Cov txiaj ntsig ntawm txoj kev tshawb fawb no tseem ceeb rau ntau yam, tsis yog qhov tsawg kawg nkaus ntawm tus nqi siab ntawm kev kuaj mob Alzheimer's tus kab mob.
Yog tias kev tshawb fawb ntxiv qhia tau tias cov zis formate tuaj yeem ntes tau kev poob qis ntawm kev paub, qhov no yuav dhau los ua qhov kev sim yooj yim siv thiab pheej yig.
Ntxiv mus, yog tias qhov kev kuaj mob zoo li no tuaj yeem pom kev poob qis ntawm kev xav uas cuam tshuam nrog tus kab mob Alzheimer, cov kws kho mob tuaj yeem cuam tshuam sai dua.
Dr. Sandra Petersen, DNP, tus lwm thawj coj ntawm kev noj qab haus huv thiab kev nyob zoo ntawm Pegasus Senior Living, tau hais rau Medical News Today txog kev tshawb fawb no:
"Kev hloov pauv ntawm tus kab mob Alzheimer pib li ntawm 20 txog 30 xyoo ua ntej kuaj pom thiab feem ntau tsis pom kom txog thaum muaj kev puas tsuaj loj heev. Peb paub tias kev kuaj pom thaum ntxov tuaj yeem ua rau muaj ntau txoj kev xaiv kho mob rau cov neeg mob thiab muaj peev xwm npaj rau kev saib xyuas yav tom ntej."
"Kev tshawb pom tshiab hauv kev kuaj mob (tsis mob hnyav thiab pheej yig) uas muaj rau pej xeem yuav yog qhov hloov pauv loj hauv kev sib ntaus sib tua kab mob Alzheimer," Dr. Peterson hais.
Cov kws tshawb fawb nyuam qhuav tshawb pom ib qho biomarker uas tuaj yeem pab cov kws kho mob kuaj mob Alzheimer's thaum ntxov. Qhov no yuav tso cai rau cov kws kho mob ...
Cov kev tshawb pom tshiab hauv nas yuav muaj ib hnub pab tsim kev kuaj ntshav uas yuav dhau los ua ib feem ntawm kev tshuaj xyuas niaj hnub rau Alzheimer's thiab lwm yam kev mob nkeeg ...
Ib txoj kev tshawb fawb tshiab siv PET lub hlwb scans los kwv yees qhov kev poob qis ntawm kev paub raws li qhov muaj cov amyloid thiab tau proteins hauv lub hlwb, ntawm lwm yam kev paub ...
Cov kws kho mob tam sim no siv ntau yam kev kuaj mob thiab kev ntsuas los kuaj mob Alzheimer's. Cov kws tshawb fawb tau tsim ib qho algorithm uas siv tau rau ib qho ...
Kev kuaj qhov muag sai sai yuav muab cov ntaub ntawv tseem ceeb txog kev noj qab haus huv ntawm lub hlwb rau ib hnub. Qhov tshwj xeeb, nws tuaj yeem kuaj pom cov cim qhia ntawm kev puas hlwb.