Cov noob caj noob ces uas koom nrog kev ua haujlwm ntawm lub cev tiv thaiv kab mob muaj cov qauv qhia tawm tsis zoo hauv lub hlwb ntawm cov neeg uas muaj qee yam kev mob hlwb thiab kev puas siab puas ntsws, suav nrog autism, raws li kev tshawb fawb tshiab ntawm ntau txhiab tus qauv hlwb tom qab tuag.
Ntawm 1,275 cov noob caj noob ces tiv thaiv kab mob uas tau kawm, 765 (60%) tau tshaj tawm lossis qis dua hauv lub hlwb ntawm cov neeg laus uas muaj ib qho ntawm rau yam kab mob: autism, schizophrenia, bipolar disorder, kev nyuaj siab, Alzheimer's disease, lossis Parkinson's disease. Cov qauv kev qhia tawm no txawv ntawm ib kis mus rau ib kis, qhia tias txhua tus muaj "kos npe tshwj xeeb," tus kws tshawb fawb Chunyu Liu, tus xibfwb ntawm kev puas siab puas ntsws thiab kev coj cwj pwm ntawm Northern State Medical University hauv Syracuse, New York tau hais.
Raws li Liu hais, qhov kev qhia tawm ntawm cov noob caj noob ces tiv thaiv kab mob tuaj yeem ua lub cim qhia txog kev o. Qhov kev ua kom lub cev tiv thaiv kab mob no, tshwj xeeb tshaj yog thaum cev xeeb tub, yog txuam nrog autism, txawm hais tias txoj hauv kev uas nws tshwm sim tsis meej.
"Kuv xav tias lub cev tiv thaiv kab mob ua lub luag haujlwm tseem ceeb hauv cov kab mob hauv lub hlwb," Liu hais. "Nws yog ib tug neeg ua si loj heev."
Christopher Coe, tus xibfwb qhia txog kev puas siab puas ntsws ntawm University of Wisconsin-Madison, uas tsis koom nrog txoj kev tshawb fawb no, tau hais tias nws tsis yooj yim to taub los ntawm txoj kev tshawb fawb seb qhov kev ua kom lub cev tiv thaiv kab mob ua lub luag haujlwm hauv kev ua rau muaj kab mob lossis tus kab mob nws tus kheej. qhov no ua rau muaj kev hloov pauv hauv kev ua kom lub cev tiv thaiv kab mob. Txoj Haujlwm.
Liu thiab nws pab neeg tau tshuaj xyuas cov qib kev qhia tawm ntawm 1,275 cov noob caj noob ces tiv thaiv kab mob hauv 2,467 cov qauv hlwb tom qab tuag, suav nrog 103 tus neeg uas muaj autism thiab 1,178 tus neeg tswj. Cov ntaub ntawv tau txais los ntawm ob lub ntaub ntawv transcriptome, ArrayExpress thiab Gene Expression Omnibus, nrog rau lwm cov kev tshawb fawb uas tau luam tawm yav dhau los.
Qib nruab nrab ntawm kev qhia tawm ntawm 275 noob caj noob ces hauv lub hlwb ntawm cov neeg mob autistic txawv ntawm qhov hauv pawg tswj; Lub hlwb ntawm cov neeg mob Alzheimer muaj 638 noob caj noob ces sib txawv, ua raws li schizophrenia (220), Parkinson's (97), bipolar (58), thiab kev nyuaj siab (27).
Cov txiv neej uas muaj autism feem ntau qhia tias lawv lub siab xav ua haujlwm txawv dua li cov poj niam uas muaj autism, thiab cov poj niam uas muaj kev nyuaj siab lub hlwb txawv dua li cov txiv neej uas muaj kev nyuaj siab. Plaub yam mob uas seem tshuav tsis qhia tias lawv muaj kev sib txawv ntawm poj niam txiv neej.
Cov qauv kev qhia tawm uas cuam tshuam nrog autism zoo li cov kab mob neurological xws li Alzheimer's thiab Parkinson's dua li lwm yam kab mob puas siab puas ntsws. Los ntawm kev txhais, cov kab mob neurological yuav tsum muaj cov yam ntxwv ntawm lub hlwb, xws li qhov poob ntawm cov dopaminergic neurons hauv Parkinson's kab mob. Cov kws tshawb fawb tseem tsis tau txhais qhov tshwj xeeb ntawm autism no.
"Qhov [kev zoo sib xws] no tsuas yog muab ib qho kev taw qhia ntxiv uas peb yuav tsum tshawb nrhiav," Liu hais. "Tej zaum muaj ib hnub peb yuav nkag siab txog kab mob zoo dua."
Ob lub noob caj noob ces, CRH thiab TAC1, feem ntau raug hloov pauv hauv cov kab mob no: CRH raug txo qis hauv txhua yam kab mob tshwj tsis yog tus kab mob Parkinson, thiab TAC1 raug txo qis hauv txhua yam kab mob tshwj tsis yog kev nyuaj siab. Ob lub noob caj noob ces cuam tshuam rau kev ua haujlwm ntawm microglia, lub hlwb lub hlwb tiv thaiv kab mob.
Coe tau hais tias qhov kev ua haujlwm ntawm microglia atypical tuaj yeem "ua rau lub hlwb tsis zoo thiab synaptogenesis tsis zoo," zoo sib xws cuam tshuam rau kev ua haujlwm ntawm neuronal hauv ntau yam mob.
Ib txoj kev tshawb fawb xyoo 2018 ntawm cov ntaub so ntswg hauv lub hlwb tom qab tuag pom tias cov noob caj noob ces cuam tshuam nrog astrocytes thiab kev ua haujlwm synaptic tau qhia tawm sib npaug zos rau cov neeg uas muaj autism, schizophrenia, lossis bipolar disorder. Tab sis kev tshawb fawb pom tias cov noob caj noob ces microglial tsuas yog overexpressed rau cov neeg mob uas muaj autism.
Cov neeg uas muaj cov noob caj noob ces tiv thaiv kab mob ntau dua yuav muaj "kab mob neuroinflammatory," Michael Benros, tus thawj coj kev tshawb fawb thiab xibfwb ntawm kev puas siab puas ntsws biological thiab precision psychiatry ntawm University of Copenhagen hauv Denmark, uas tsis koom nrog hauv txoj haujlwm no tau hais.
"Nws yuav yog qhov nthuav kom sim txheeb xyuas cov pab pawg me no thiab muab kev kho mob tshwj xeeb rau lawv," Benroth hais.
Cov kev tshawb fawb pom tau tias feem ntau ntawm cov kev hloov pauv ntawm kev qhia tawm uas pom hauv cov qauv ntaub so ntswg ntawm lub hlwb tsis muaj nyob rau hauv cov ntaub ntawv ntawm cov qauv kev qhia tawm ntawm cov noob caj noob ces hauv cov qauv ntshav los ntawm cov neeg uas muaj tib yam kab mob. Qhov kev tshawb pom "qee yam tsis tau xav txog" qhia txog qhov tseem ceeb ntawm kev kawm txog kev teeb tsa ntawm lub hlwb, Cynthia Schumann, xibfwb ntawm kev puas siab puas ntsws thiab kev coj cwj pwm ntawm MIND Institute ntawm UC Davis, uas tsis koom nrog hauv kev tshawb fawb no, tau hais.
Liu thiab nws pab neeg tab tom tsim cov qauv cellular kom nkag siab zoo dua seb qhov o yog ib qho ua rau muaj kab mob hauv lub hlwb.
Tsab xov xwm no tau luam tawm thawj zaug ntawm Spectrum, lub vev xaib xov xwm tshawb fawb txog autism. Hais txog tsab xov xwm no: https://doi.org/10.53053/UWCJ7407