Tsab xov xwm no tau raug tshuaj xyuas raws li Science X cov txheej txheem kho thiab cov cai. Cov neeg kho tau hais txog cov yam ntxwv hauv qab no thaum ua kom ntseeg tau tias cov ntsiab lus muaj kev ncaj ncees:
Cov txheej sab nraud nplaum ntawm cov kab mob fungi thiab cov kab mob, hu ua "extracellular matrix" lossis ECM, muaj qhov sib xws ntawm jelly thiab ua haujlwm ua ib txheej tiv thaiv thiab plhaub. Tab sis raws li kev tshawb fawb tsis ntev los no luam tawm hauv phau ntawv xov xwm iScience, ua los ntawm University of Massachusetts Amherst ua ke nrog Worcester Polytechnic Institute, ECM ntawm qee cov kab mob me me tsim cov gel tsuas yog nyob rau hauv qhov muaj oxalic acid lossis lwm yam acids yooj yim. googletag.cmd.push(function() { googletag.display('div-gpt-ad-1449240174198-2′); });
Vim tias ECM ua lub luag haujlwm tseem ceeb hauv txhua yam los ntawm kev tiv thaiv tshuaj tua kab mob mus rau cov kav dej txhaws thiab kev ua qias tuaj ntawm cov khoom siv kho mob, kev nkag siab txog yuav ua li cas cov kab mob me me tswj lawv cov txheej gel nplaum muaj feem cuam tshuam dav rau peb lub neej txhua hnub.
"Kuv yeej ib txwm xav paub txog cov microbial ECMs," Barry Goodell, xib fwb qhia txog microbiology ntawm University of Massachusetts Amherst thiab tus sau ntawv laus ntawm daim ntawv no hais. "Cov neeg feem ntau xav txog ECM ua ib txheej tiv thaiv sab nraud uas tiv thaiv cov kab mob me me. Tab sis nws kuj tseem tuaj yeem ua haujlwm ua ib txoj kab uas tso cai rau cov as-ham thiab cov enzymes txav mus rau hauv thiab tawm ntawm cov hlwb microbial."
Cov txheej txheej no ua haujlwm ntau yam: nws qhov nplaum txhais tau tias cov kab mob me me tuaj yeem sib sau ua ke los ua cov pawg lossis "biofilms", thiab thaum cov kab mob me me txaus ua qhov no, nws tuaj yeem txhaws cov kav dej lossis ua rau cov khoom siv kho mob qias neeg.
Tiam sis lub plhaub kuj yuav tsum tau nkag tau. Ntau yam kab mob me me tso tawm ntau yam enzymes thiab lwm yam metabolites los ntawm ECM mus rau hauv cov khoom uas lawv xav noj lossis kis kab mob (xws li ntoo lwj lossis cov nqaij vertebrate), thiab tom qab ntawd, thaum cov enzymes ua tiav lawv txoj haujlwm zom zaub mov, txav cov as-ham los ntawm ECM. cov tshuaj lom neeg raug nqus rov qab rau hauv lub cev. extracellular matrix.
Qhov no txhais tau hais tias ECM tsis yog ib txheej tiv thaiv inert xwb; Qhov tseeb, raws li Goodell thiab cov npoj yaig tau ua pov thawj, cov kab mob me me zoo li muaj peev xwm tswj tau qhov nplaum ntawm lawv cov ECM thiab yog li ntawd lawv qhov permeability. Lawv ua li cas? Duab credit: B. Goodell
Hauv cov nceb, cov kua qaub no zoo li yog oxalic acid, ib hom organic acid uas pom muaj nyob hauv ntau hom nroj tsuag. Raws li Goodell thiab nws cov npoj yaig tau tshawb pom, ntau cov kab mob me me zoo li siv cov oxalic acid uas lawv tso tawm los khi rau txheej sab nraud ntawm cov carbohydrates, tsim cov ECM nplaum, zoo li gel.
Tab sis thaum pab neeg saib ze dua, lawv pom tias oxalic acid tsis yog tsuas yog pab tsim ECM xwb, tab sis kuj "tswj" nws: qhov ntau oxalic acid uas cov kab mob ntxiv rau hauv cov carbohydrate-acid sib tov, qhov ntau viscous ECM dhau los ua. Qhov ntau viscous ECM dhau los ua, qhov ntau nws thaiv cov molecules loj los ntawm kev nkag mus lossis tawm hauv cov microbe, thaum cov molecules me me tseem muaj kev ywj pheej nkag mus rau hauv cov microbe los ntawm ib puag ncig thiab vice versa.
Qhov kev tshawb pom no ua rau muaj kev sib tw rau kev nkag siab txog kev tshawb fawb ib txwm muaj txog li cas cov tshuaj sib txawv uas cov kab mob fungi thiab cov kab mob me me tso tawm tau los ntawm cov kab mob me me no mus rau hauv ib puag ncig. Goodell thiab cov npoj yaig tau hais tias qee zaum cov kab mob me me yuav tsum tau cia siab rau kev tso tawm ntawm cov molecule me me heev los tawm tsam lub matrix lossis cov ntaub so ntswg uas cov kab mob me me nyob ntawm kom muaj sia nyob lossis kis tus kab mob.
Qhov no txhais tau tias kev tso tawm ntawm cov molecule me me kuj tseem yuav ua lub luag haujlwm loj hauv pathogenesis yog tias cov enzymes loj dua tsis tuaj yeem hla dhau cov microbial extracellular matrix.
"Zoo li muaj ib qho chaw nruab nrab," Goodell hais tias, "qhov twg cov kab mob me me tuaj yeem tswj cov qib acidity kom hloov mus rau ib puag ncig tshwj xeeb, khaws qee cov molecule loj dua, xws li enzymes, thaum tso cai rau cov molecule me dua kom yooj yim hla dhau ECM."
Kev hloov kho ntawm ECM los ntawm oxalic acid tej zaum yuav yog ib txoj hauv kev rau cov kab mob me me los tiv thaiv lawv tus kheej los ntawm cov tshuaj tua kab mob thiab tshuaj tua kab mob, vim tias ntau cov tshuaj no yog tsim los ntawm cov molecules loj heev. Nws yog qhov peev xwm hloov kho no uas yuav yog qhov tseem ceeb rau kev kov yeej ib qho ntawm cov teeb meem loj hauv kev kho mob antimicrobial, vim tias kev tswj hwm ECM kom nws nkag tau ntau dua tuaj yeem txhim kho qhov ua tau zoo ntawm cov tshuaj tua kab mob thiab cov tshuaj tua kab mob.
"Yog tias peb tuaj yeem tswj tau qhov biosynthesis thiab kev tso tawm ntawm cov kua qaub me me xws li oxalate hauv qee cov kab mob me me, peb kuj tuaj yeem tswj tau qhov nkag mus rau hauv cov kab mob me me, uas tuaj yeem ua rau peb kho tau ntau yam kab mob me me zoo dua," Goodell hais.
Cov ntaub ntawv ntxiv: Gabriel Perez-Gonzalez et al., Kev sib cuam tshuam ntawm oxalates nrog beta-glucan: kev cuam tshuam rau fungal extracellular matrix thiab metabolite transport, iScience (2023). DOI: 10.1016/j.isci.2023.106851
Yog tias koj ntsib teeb meem sau yuam kev, tsis raug, lossis xav xa daim ntawv thov kom hloov kho cov ntsiab lus ntawm nplooj ntawv no, thov siv daim foos no. Yog tias muaj lus nug dav dav, thov siv peb daim foos tiv tauj. Yog xav tau cov lus taw qhia dav dav, siv ntu lus tawm tswv yim rau pej xeem hauv qab no (ua raws li cov lus qhia).
Koj cov lus taw qhia tseem ceeb heev rau peb. Txawm li cas los xij, vim muaj ntau cov lus xa tuaj, peb tsis tuaj yeem lav tias yuav teb rau koj raws li koj xav tau.
Koj qhov chaw nyob email tsuas yog siv los qhia rau cov neeg tau txais uas yog tus xa email xwb. Koj qhov chaw nyob lossis tus neeg tau txais qhov chaw nyob yuav tsis raug siv rau lwm yam hom phiaj. Cov ntaub ntawv koj sau yuav tshwm sim hauv koj tus email thiab yuav tsis raug khaws cia los ntawm Phys.org hauv txhua daim ntawv.
Tau txais cov xov xwm tshiab txhua lub lim tiam thiab/lossis txhua hnub hauv koj lub inbox. Koj tuaj yeem tshem tawm koj cov ntaub ntawv txhua lub sijhawm thiab peb yuav tsis qhia koj cov ntaub ntawv rau cov neeg thib peb.
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