Ib tug kws tshawb fawb Fabkis tau tsa kev paub txog qhov txaus ntshai ntawm cov koob ntse hauv chav kuaj mob tom qab muaj xwm txheej txaus ntshai uas cuam tshuam nrog kev xau cov tshuaj yaj. Tam sim no nws hu kom tsim cov koob hloov rau kev hloov cov tshuaj yaj lossis cov tshuaj reagents kom txhim kho kev nyab xeeb hauv chav kuaj mob. 1
Thaum Lub Rau Hli 2018, tus tub ntxhais kawm hnub nyoog 22 xyoo Nicolas tau ua haujlwm hauv chav kuaj mob ntawm Sebastien Vidal ntawm University of Lyon 1. Nws nchuav ib lub koob txhaj tshuaj dichloromethane (DXM) rau hauv ib lub raj mis thiab ua rau nws tus ntiv tes raug chob. Vidal xam tias muaj li ob tee lossis tsawg dua 100 microliters ntawm DXM tseem nyob hauv koob txhaj tshuaj thiab nkag mus rau hauv tus ntiv tes.
Muaj cov duab kos qhia txog yam uas tau tshwm sim tom ntej - tsab xov xwm hauv phau ntawv xov xwm ceeb toom tias qee tus yuav pom cov duab (hauv qab no) ua rau ntxhov siab. Kwv yees li 15 feeb tom qab koob raug chob, Nicolas tau tsim ib qho chaw ntshav ntawm nws tus ntiv tes. Ob teev tom qab, cov npoo ntawm cov plaques ntshav pib tsaus ntuj, qhia txog qhov pib ntawm necrosis - kev tuag ntawm tes. Thaum lub sijhawm no, Nicholas yws tias nws cov ntiv tes kub thiab nws tsis tuaj yeem txav lawv.
Nicholas yuav tsum tau phais mob ceev kom cawm nws tus ntiv tes. Cov kws phais, uas thaum xub thawj xav tias nws yuav tsum tau txiav nws txhais tes, tau tshem tawm cov tawv nqaij tuag nyob ib puag ncig qhov txhab thiab kho tus ntiv tes dua tshiab siv daim tawv nqaij los ntawm Nicholas txhais tes. Tus kws phais tom qab ntawd nco qab tias hauv nws 25 xyoo ua haujlwm hauv chav kho mob ceev, nws yeej tsis tau pom qhov raug mob zoo li no.
Nicholas cov ntiv tes tam sim no yuav luag rov qab zoo li qub, txawm hais tias nws qhov kev ua si guitar raug kev txom nyem los ntawm necrosis uas ua rau nws cov hlab ntsha puas tsuaj, ua rau nws lub zog thiab kev txawj ntse tsis muaj zog.
DCM yog ib qho ntawm cov organic solvents uas siv ntau tshaj plaws hauv cov chaw kuaj tshuaj synthetic chemistry. Cov Ntaub Ntawv Txog Kev Raug Mob DCM thiab nws Daim Ntawv Qhia Txog Kev Nyab Xeeb Khoom Siv (MSDS) muab cov ntsiab lus ntawm kev sib cuag ntawm qhov muag, kev sib cuag ntawm daim tawv nqaij, kev noj thiab kev nqus pa, tab sis tsis yog thaum txhaj tshuaj, Vidal tau sau tseg. Thaum lub sijhawm tshawb nrhiav, Vidal pom tias muaj qhov xwm txheej zoo sib xws tshwm sim hauv Thaib teb, txawm hais tias tus txiv neej tau txhaj tshuaj rau nws tus kheej nrog 2 milliliters ntawm dichloromethane, uas cov txiaj ntsig tau tshaj tawm hauv tsev kho mob Bangkok.
Cov rooj plaub no qhia tau tias cov ntaub ntawv MSDS yuav tsum tau hloov kom muaj cov ntaub ntawv ntsig txog kev txhaj tshuaj, Vidal hais. "Tab sis kuv tus neeg saib xyuas kev ruaj ntseg ntawm tsev kawm ntawv tau hais rau kuv tias kev hloov kho cov ntaub ntawv MSDS yuav siv sijhawm ntev thiab xav tau ntau cov ntaub ntawv los sau." Cov no suav nrog kev tshawb fawb txog tsiaj txhu kom ntxaws txog qhov xwm txheej, kev tshuaj xyuas cov nqaij puas tsuaj, thiab kev ntsuam xyuas kev kho mob.
Cov ntiv tes ntawm cov tub ntxhais kawm nyob rau ntau theem tom qab raug txhaj tshuaj me me ntawm methylene chloride tsis raug. Los ntawm sab laug mus rau sab xis, 10-15 feeb tom qab raug mob, tom qab ntawd 2 teev, 24 teev (tom qab phais), 2 hnub, 5 hnub, thiab 1 xyoos (ob daim duab hauv qab)
Vim tsis muaj cov ntaub ntawv hais txog kev siv DCM, Vidal vam tias zaj dab neeg no yuav raug tshaj tawm dav dav. Cov lus tawm tswv yim zoo. Nws hais tias daim ntawv tau [thoob plaws]. "Cov tub ceev xwm kev ruaj ntseg los ntawm cov tsev kawm ntawv qib siab hauv Canada, Tebchaws Meskas thiab Fabkis tau hais rau kuv tias lawv yuav muab zaj dab neeg no tso rau hauv lawv cov kev kawm. Cov neeg ua tsaug rau peb rau kev qhia zaj dab neeg no. Muaj ntau tus tsis xav tham txog nws vim ntshai tsam muaj kev tshaj tawm tsis zoo [rau lawv lub koom haum] Tab sis peb lub koom haum tau txhawb nqa zoo heev txij thaum pib thiab tseem yog.
Vidal kuj xav kom cov zej zog tshawb fawb thiab cov neeg muab tshuaj lom neeg tsim cov txheej txheem muaj kev nyab xeeb dua thiab lwm yam khoom siv rau cov txheej txheem niaj hnub xws li kev hloov tshuaj. Ib lub tswv yim yog siv rab koob "taw tes tiaj tus" kom tsis txhob muaj qhov txhab. "Lawv muaj tam sim no, tab sis peb feem ntau siv rab koob taw tes hauv cov tshuaj lom neeg vim peb xav tau cov tshuaj yaj los ntawm cov roj hmab stoppers los tiv thaiv peb cov hlab ntsha los ntawm huab cua / dej noo sab nraud. Cov koob "taw tes tiaj tus" tsis tuaj yeem hla dhau cov roj hmab stoppers. Qhov no tsis yog ib lo lus nug yooj yim, tab sis tej zaum qhov kev ua tsis tiav no yuav ua rau muaj cov tswv yim zoo.
Alain Martin, tus thawj coj saib xyuas kev noj qab haus huv thiab kev nyab xeeb ntawm University of Strathclyde's Department of Chemistry, tau hais tias nws yeej tsis tau pom qhov xwm txheej zoo li no. "Hauv chav kuaj, cov koob txhaj tshuaj nrog koob feem ntau yog siv, tab sis yog tias qhov tseeb yog qhov tseem ceeb, ces siv micropipettes yuav yog qhov kev xaiv zoo dua," nws hais ntxiv, nyob ntawm kev cob qhia, xws li xaiv cov lus qhia thiab siv pipettes kom raug. "Peb cov tub ntxhais kawm puas tau kawm paub yuav ua li cas tuav cov koob kom raug, yuav ua li cas ntxig thiab tshem cov koob?" nws nug. "Muaj leej twg xav tias lwm yam dab tsi siv tau? Tej zaum tsis muaj.
2 K. Sanprasert, T. Thangtrongchitr thiab N. Krairojananan, Asia. Pob. J. Med. Toxicology, 2018, 7, 84 (DOI: 10.22038/apjmt.2018.11981)
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